STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AYI68_g4367tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (354 aa)    
Predicted Functional Partners:
AYI68_g5643
Pre-mRNA-splicing factor RBM22.
   
 0.969
AYI68_g843
Uncharacterized protein.
    
 0.943
AYI68_g6568
60S ribosomal protein L9-A.
    
 0.896
AYI68_g7108
Heat shock protein 75 kDa, mitochondrial.
   
 0.877
AYI68_g6743
Heat shock protein 75 kDa, mitochondrial.
   
 0.877
AYI68_g2249
Heat shock protein HSP 90-alpha 1.
   
 0.877
AYI68_g1806
DNA damage-responsive transcriptional repressor RPH1.
    
 0.877
AYI68_g3630
50S ribosomal protein L6; Belongs to the universal ribosomal protein uL6 family.
    
 0.839
AYI68_g4081
Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.818
AYI68_g2190
B box-type domain-containing protein.
    
 0.818
Your Current Organism:
Smittium mucronatum
NCBI taxonomy Id: 133383
Other names: S. mucronatum
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