STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BB561_003953Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (185 aa)    
Predicted Functional Partners:
BB561_002668
GTP_cyclohydroI domain-containing protein.
  
 
 0.910
BB561_001597
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 0.908
BB561_001002
PRAI domain-containing protein.
  
  0.903
BB561_006393
Glutamine amidotransferase type-1 domain-containing protein.
  
  0.902
BB561_005925
Vacuolar protein sorting-associated protein 29; Belongs to the VPS29 family.
  
  
 0.900
BB561_000083
Uncharacterized protein.
  
 
 0.893
BB561_000917
Thymidylat_synt domain-containing protein.
  
 
 0.886
BB561_004263
Guanylate kinase-like domain-containing protein.
  
 
 0.871
BB561_005983
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
   
 
 0.861
BB561_006079
Uncharacterized protein; Belongs to the adenylate kinase family.
    
 0.858
Your Current Organism:
Smittium simulii
NCBI taxonomy Id: 133385
Other names: S. simulii, Smittium simuli
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.