AYI70_g6949 protein (Smittium culicis) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

AYI70_g6949

26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (430 aa)

Predicted Functional Partners:

AYI70_g11462

0.999

AYI70_g2365

0.999

AYI70_g2519

0.999

AYI70_g11189

0.998

AYI70_g1111

0.998

AYI70_g7184

0.998

AYI70_g7091

0.998

AYI70_g4047

0.998

AYI70_g585

0.998

AYI70_g556

0.998

Your Current Organism:

Smittium culicis

NCBI taxonomy Id: 133412
Other names: S. culicis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYI70_g1111	AYI70_g11189	A0A1R1XB50	A0A1R1X300	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 14.	0.999
AYI70_g1111	AYI70_g11462	A0A1R1XB50	A0A1R1WZV7	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.999
AYI70_g1111	AYI70_g2365	A0A1R1XB50	A0A1R1XZ07	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999
AYI70_g1111	AYI70_g2519	A0A1R1XB50	A0A1R1Y7U3	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 12.	0.999
AYI70_g1111	AYI70_g4047	A0A1R1XB50	A0A1R1Y0W5	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S protease regulatory subunit 7; Belongs to the AAA ATPase family.	0.999
AYI70_g1111	AYI70_g556	A0A1R1XB50	A0A1R1YGC1	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	Putative 26S proteasome non-ATPase regulatory subunit 8.	0.999
AYI70_g1111	AYI70_g585	A0A1R1XB50	A0A1R1YG53	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	Putative 26S proteasome regulatory subunit rpn9.	0.999
AYI70_g1111	AYI70_g6949	A0A1R1XB50	A0A1R1XMN9	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.998
AYI70_g1111	AYI70_g7091	A0A1R1XB50	A0A1R1XM52	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S proteasome regulatory subunit rpn-8.	0.999
AYI70_g1111	AYI70_g7184	A0A1R1XB50	A0A1R1XLR6	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	26S proteasome non-ATPase regulatory subunit 6.	0.999
AYI70_g11189	AYI70_g1111	A0A1R1X300	A0A1R1XB50	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 6B-like protein; Belongs to the AAA ATPase family.	0.999
AYI70_g11189	AYI70_g11462	A0A1R1X300	A0A1R1WZV7	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.999
AYI70_g11189	AYI70_g2365	A0A1R1X300	A0A1R1XZ07	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999
AYI70_g11189	AYI70_g2519	A0A1R1X300	A0A1R1Y7U3	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome non-ATPase regulatory subunit 12.	0.999
AYI70_g11189	AYI70_g4047	A0A1R1X300	A0A1R1Y0W5	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 7; Belongs to the AAA ATPase family.	0.999
AYI70_g11189	AYI70_g556	A0A1R1X300	A0A1R1YGC1	26S proteasome non-ATPase regulatory subunit 14.	Putative 26S proteasome non-ATPase regulatory subunit 8.	0.999
AYI70_g11189	AYI70_g585	A0A1R1X300	A0A1R1YG53	26S proteasome non-ATPase regulatory subunit 14.	Putative 26S proteasome regulatory subunit rpn9.	0.999
AYI70_g11189	AYI70_g6949	A0A1R1X300	A0A1R1XMN9	26S proteasome non-ATPase regulatory subunit 14.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.998
AYI70_g11189	AYI70_g7091	A0A1R1X300	A0A1R1XM52	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome regulatory subunit rpn-8.	0.999
AYI70_g11189	AYI70_g7184	A0A1R1X300	A0A1R1XLR6	26S proteasome non-ATPase regulatory subunit 14.	26S proteasome non-ATPase regulatory subunit 6.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

12

PPI enrichment p-value:

0.101

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051403

Stress-activated MAPK cascade

4 of 13

2.53

3.18

9.53e-07

GO:0006468

Protein phosphorylation

9 of 297

1.52

2.7

6.35e-10

GO:0051301

Cell division

5 of 132

1.62

1.89

2.46e-05

GO:0071310

Cellular response to organic substance

4 of 87

1.71

1.62

0.00026

GO:0071554

Cell wall organization or biogenesis

4 of 130

1.53

1.28

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004709

MAP kinase kinase kinase activity

4 of 6

2.87

4.16

1.91e-08

GO:0004674

Protein serine/threonine kinase activity

9 of 249

1.6

3.1

6.11e-11

GO:0005524

ATP binding

9 of 948

1.02

1.16

1.04e-06

GO:1901363

Heterocyclic compound binding

10 of 2877

0.58

0.49

0.00035

GO:0097159

Organic cyclic compound binding

10 of 2896

0.58

0.48

0.00036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10482

MADS SRF-like, and Hippo signaling pathway - multiple species

6 of 17

2.59

5.49

1.88e-11

CL:10485

MADS SRF-like, and Smooth muscle protein/calponin

5 of 10

2.74

5.04

2.84e-10

CL:4336

Stress-activated MAPK cascade

4 of 11

2.6

3.57

1.79e-07

CL:4338

MAPK1 (ERK2) activation, and MAP kinase kinase kinase activity

2 of 6

2.57

1.35

0.0034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

5 of 9

2.79

5.41

6.06e-11

map04111

Cell cycle - yeast

6 of 127

1.72

2.79

4.92e-08

map04113

Meiosis - yeast

5 of 148

1.57

1.99

6.23e-06

map04011

MAPK signaling pathway - yeast

5 of 221

1.4

1.58

3.26e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2871796

FCERI mediated MAPK activation

5 of 13

2.63

4.59

1.68e-09

MAP-2454202

Fc epsilon receptor (FCERI) signaling

5 of 34

2.21

3.53

5.60e-08

MAP-168256

Immune System

9 of 798

1.09

1.33

3.69e-07

MAP-168249

Innate Immune System

5 of 517

1.03

0.67

0.0126

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005816

Spindle pole body

5 of 28

2.29

3.65

4.71e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 371

1.43

2.45

3.42e-10

KW-0067

ATP-binding

6 of 531

1.1

1.04

0.00023

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001245

Serine-threonine/tyrosine-protein kinase, catalytic domain

7 of 13

2.77

7.23

1.14e-14

IPR046349

C1-like domain superfamily

5 of 17

2.51

4.37

3.17e-09

IPR002219

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

5 of 17

2.51

4.37

3.17e-09

IPR017441

Protein kinase, ATP binding site

9 of 187

1.73

3.7

5.71e-12

IPR000719

Protein kinase domain

9 of 256

1.59

3.06

5.98e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00220

Serine/Threonine protein kinases, catalytic domain

9 of 159

1.8

4.22

3.03e-13

SM00033

Calponin homology domain

4 of 17

2.41

3.3

4.08e-07

SM00109

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

3 of 14

2.37

2.28

4.70e-05

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