AKL17_0032 protein (Defluviimonas alba) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

AKL17_0032

TRAP-T family transporter, large inner membrane subunit. (494 aa)

Predicted Functional Partners:

AKL17_0031

0.993

AKL17_0030

0.944

AKL17_0981

0.865

AKL17_0984

0.865

AKL17_1010

0.865

AKL17_3612

0.865

AKL17_4663

0.865

AKL17_3258

0.864

AKL17_1870

0.862

AKL17_3723

0.849

Your Current Organism:

Defluviimonas alba

NCBI taxonomy Id: 1335048
Other names: CGMCC 1.12518, D. alba, Defluviimonas alba Pan et al. 2015, LMG 27406, LMG:27406, Rhodobacter sp. b45, Rhodobacter sp. cai42, strain cai42

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
AKL17_0030	AKL17_0031	TRAP-T family transporter small inner membrane subunit.	TRAP-T family transporter periplasmic binding protein.	0.964
AKL17_0030	AKL17_0032	TRAP-T family transporter small inner membrane subunit.	TRAP-T family transporter, large inner membrane subunit.	0.944
AKL17_0031	AKL17_0030	TRAP-T family transporter periplasmic binding protein.	TRAP-T family transporter small inner membrane subunit.	0.964
AKL17_0031	AKL17_0032	TRAP-T family transporter periplasmic binding protein.	TRAP-T family transporter, large inner membrane subunit.	0.993
AKL17_0032	AKL17_0030	TRAP-T family transporter, large inner membrane subunit.	TRAP-T family transporter small inner membrane subunit.	0.944
AKL17_0032	AKL17_0031	TRAP-T family transporter, large inner membrane subunit.	TRAP-T family transporter periplasmic binding protein.	0.993
AKL17_0032	AKL17_0981	TRAP-T family transporter, large inner membrane subunit.	Hypothetical protein.	0.865
AKL17_0032	AKL17_0984	TRAP-T family transporter, large inner membrane subunit.	Hypothetical protein.	0.865
AKL17_0032	AKL17_1010	TRAP-T family transporter, large inner membrane subunit.	Twin-arginine translocation pathway signal.	0.865
AKL17_0032	AKL17_1870	TRAP-T family transporter, large inner membrane subunit.	TRAP-T family transporter periplasmic binding protein.	0.862
AKL17_0032	AKL17_3258	TRAP-T family transporter, large inner membrane subunit.	Hypothetical protein.	0.864
AKL17_0032	AKL17_3612	TRAP-T family transporter, large inner membrane subunit.	Extra-cytoplasmic solute receptor family protein 48.	0.865
AKL17_0032	AKL17_3723	TRAP-T family transporter, large inner membrane subunit.	Hypothetical protein.	0.849
AKL17_0032	AKL17_4663	TRAP-T family transporter, large inner membrane subunit.	Hypothetical protein.	0.865
AKL17_0981	AKL17_0032	Hypothetical protein.	TRAP-T family transporter, large inner membrane subunit.	0.865
AKL17_0981	AKL17_0984	Hypothetical protein.	Hypothetical protein.	0.557
AKL17_0984	AKL17_0032	Hypothetical protein.	TRAP-T family transporter, large inner membrane subunit.	0.865
AKL17_0984	AKL17_0981	Hypothetical protein.	Hypothetical protein.	0.557
AKL17_1010	AKL17_0032	Twin-arginine translocation pathway signal.	TRAP-T family transporter, large inner membrane subunit.	0.865
AKL17_1870	AKL17_0032	TRAP-T family transporter periplasmic binding protein.	TRAP-T family transporter, large inner membrane subunit.	0.862

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.899

expected number of edges:

11

PPI enrichment p-value:

2.1e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

8 of 63

2.09

5.02

1.47e-12

GO:0006120

Mitochondrial electron transport, NADH to ubiquinone

4 of 9

2.63

3.54

2.17e-07

GO:0042773

ATP synthesis coupled electron transport

5 of 33

2.17

3.32

1.41e-07

GO:0009060

Aerobic respiration

6 of 74

1.9

3.06

7.78e-08

GO:0032981

Mitochondrial respiratory chain complex I assembly

4 of 17

2.36

3.03

1.29e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

10 of 23

2.63

10.29

3.07e-22

GO:0051539

4 iron, 4 sulfur cluster binding

6 of 48

2.08

4.07

8.29e-10

GO:0048038

Quinone binding

2 of 13

2.17

1.08

0.0095

GO:0051537

2 iron, 2 sulfur cluster binding

2 of 27

1.86

0.77

0.0344

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005747

Mitochondrial respiratory chain complex I

9 of 23

2.58

8.94

2.58e-19

GO:0070469

Respirasome

10 of 54

2.25

7.75

2.58e-19

GO:0005743

Mitochondrial inner membrane

10 of 238

1.61

3.61

3.11e-14

GO:0016020

Membrane

11 of 2513

0.63

0.58

4.79e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9737

Complex I biogenesis

10 of 26

2.57

9.89

1.00e-21

CL:9739

Complex I biogenesis

9 of 20

2.64

9.35

7.00e-20

CL:9704

Respiratory electron transport, and NAD(P)H-binding

11 of 99

2.03

6.76

7.00e-20

CL:9741

Complex I biogenesis

6 of 14

2.62

6.19

6.86e-13

CL:9769

NADH dehydrogenase (quinone) activity

3 of 5

2.76

2.96

3.46e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

10 of 146

1.82

4.86

5.59e-16

map01100

Metabolic pathways

10 of 3184

0.48

0.38

0.0035

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

11 of 33

2.51

10.72

1.39e-24

MAP-611105

Respiratory electron transport

11 of 70

2.18

8.06

1.10e-21

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

11 of 82

2.11

7.53

3.69e-21

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

11 of 155

1.84

5.36

2.14e-18

MAP-1430728

Metabolism

11 of 2027

0.72

0.7

2.23e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

6 of 63

1.97

3.33

2.62e-08

GOCC:0005743

Mitochondrial inner membrane

5 of 159

1.48

1.5

0.00017

GOCC:0005747

Mitochondrial respiratory chain complex I

2 of 7

2.44

1.28

0.0043

GOCC:0005739

Mitochondrion

7 of 736

0.97

0.86

0.00039

GOCC:0016020

Membrane

9 of 1543

0.75

0.65

0.00029

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

3 of 36

1.91

1.39

0.0017

KW-0679

Respiratory chain

2 of 8

2.38

1.24

0.0052

KW-0004

4Fe-4S

2 of 13

2.17

1.12

0.0080

KW-0999

Mitochondrion inner membrane

2 of 32

1.78

0.86

0.0212

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00384

Molybdopterin oxidoreductase

2 of 2

2.99

1.23

0.0061

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006963

Molybdopterin oxidoreductase, 4Fe-4S domain

2 of 2

2.99

0.98

0.0169

IPR006656

Molybdopterin oxidoreductase

2 of 2

2.99

0.98

0.0169

IPR008011

Complex 1 LYR protein domain

2 of 7

2.44

0.81

0.0337

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