SIR65421.1 protein (Williamsia sterculiae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

SIR65421.1

Hypothetical protein. (670 aa)

Predicted Functional Partners:

SIR65406.1

0.723

SIR80070.1

0.670

SIR65477.1

0.665

SIR65434.1

0.656

SIR79074.1

0.638

SIR61244.1

0.613

SIR86295.1

0.588

SIS17187.1

0.569

SIS23779.1

0.548

SIS22776.1

0.523

Your Current Organism:

Williamsia sterculiae

NCBI taxonomy Id: 1344003
Other names: CPCC 203464, DSM 45741, KCTC 29118, W. sterculiae, Williamsia sp. I12A-00824, Williamsia sp. I12A-01109, Williamsia sterculiae Fang et al. 2013, strain I12A-01109

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIR61244.1	SIR65421.1	SAMN05445060_0036	SAMN05445060_0269	NTF2-like N-terminal transpeptidase domain-containing protein.	Hypothetical protein.	0.613
SIR61244.1	SIR65477.1	SAMN05445060_0036	SAMN05445060_0271	NTF2-like N-terminal transpeptidase domain-containing protein.	Uncharacterized membrane protein YgaE, UPF0421/DUF939 family.	0.609
SIR61244.1	SIR79074.1	SAMN05445060_0036	SAMN05445060_0891	NTF2-like N-terminal transpeptidase domain-containing protein.	Type VII secretion-associated protein, Rv3446c family, C-terminal domain-containing protein.	0.737
SIR61244.1	SIR80070.1	SAMN05445060_0036	SAMN05445060_0961	NTF2-like N-terminal transpeptidase domain-containing protein.	Hypothetical protein.	0.768
SIR61244.1	SIR86295.1	SAMN05445060_0036	SAMN05445060_1203	NTF2-like N-terminal transpeptidase domain-containing protein.	Hypothetical protein.	0.741
SIR61244.1	SIS17187.1	SAMN05445060_0036	SAMN05445060_3219	NTF2-like N-terminal transpeptidase domain-containing protein.	Protein of unknown function.	0.693
SIR61244.1	SIS23779.1	SAMN05445060_0036	SAMN05445060_4178	NTF2-like N-terminal transpeptidase domain-containing protein.	Part of AAA domain-containing protein.	0.660
SIR65406.1	SIR65421.1	SAMN05445060_0268	SAMN05445060_0269	Hypothetical protein.	Hypothetical protein.	0.723
SIR65406.1	SIR65434.1	SAMN05445060_0268	SAMN05445060_0270	Hypothetical protein.	Protein of unknown function.	0.471
SIR65406.1	SIR65477.1	SAMN05445060_0268	SAMN05445060_0271	Hypothetical protein.	Uncharacterized membrane protein YgaE, UPF0421/DUF939 family.	0.471
SIR65421.1	SIR61244.1	SAMN05445060_0269	SAMN05445060_0036	Hypothetical protein.	NTF2-like N-terminal transpeptidase domain-containing protein.	0.613
SIR65421.1	SIR65406.1	SAMN05445060_0269	SAMN05445060_0268	Hypothetical protein.	Hypothetical protein.	0.723
SIR65421.1	SIR65434.1	SAMN05445060_0269	SAMN05445060_0270	Hypothetical protein.	Protein of unknown function.	0.656
SIR65421.1	SIR65477.1	SAMN05445060_0269	SAMN05445060_0271	Hypothetical protein.	Uncharacterized membrane protein YgaE, UPF0421/DUF939 family.	0.665
SIR65421.1	SIR79074.1	SAMN05445060_0269	SAMN05445060_0891	Hypothetical protein.	Type VII secretion-associated protein, Rv3446c family, C-terminal domain-containing protein.	0.638
SIR65421.1	SIR80070.1	SAMN05445060_0269	SAMN05445060_0961	Hypothetical protein.	Hypothetical protein.	0.670
SIR65421.1	SIR86295.1	SAMN05445060_0269	SAMN05445060_1203	Hypothetical protein.	Hypothetical protein.	0.588
SIR65421.1	SIS17187.1	SAMN05445060_0269	SAMN05445060_3219	Hypothetical protein.	Protein of unknown function.	0.569
SIR65421.1	SIS22776.1	SAMN05445060_0269	SAMN05445060_4020	Hypothetical protein.	Urea carboxylase.	0.523
SIR65421.1	SIS23779.1	SAMN05445060_0269	SAMN05445060_4178	Hypothetical protein.	Part of AAA domain-containing protein.	0.548

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.887

expected number of edges:

16

PPI enrichment p-value:

2.23e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045892

Negative regulation of transcription, DNA-templated

8 of 599

1.23

1.45

5.61e-06

GO:0051172

Negative regulation of nitrogen compound metabolic process

10 of 1220

1.01

1.12

2.62e-06

GO:0070544

Histone H3-K36 demethylation

2 of 7

2.56

1.12

0.0090

GO:0035518

Histone H2A monoubiquitination

2 of 8

2.5

1.09

0.0102

GO:0010605

Negative regulation of macromolecule metabolic process

10 of 1414

0.95

1.0

5.61e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140680

Histone H3-di/monomethyl-lysine-36 demethylase activity

2 of 3

2.92

1.18

0.0074

GO:0003682

Chromatin binding

5 of 314

1.3

0.89

0.0067

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031519

PcG protein complex

4 of 23

2.34

2.75

4.85e-06

GO:0035102

PRC1 complex

3 of 7

2.73

2.47

2.89e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1795

PcG protein complex, and RNA binding Region

8 of 20

2.7

8.24

4.74e-17

CL:1799

PcG protein complex

5 of 15

2.62

4.78

6.52e-10

CL:1802

RAWUL domain RING finger- and WD40-associated ubiquitin-like

3 of 5

2.88

2.81

7.19e-06

CL:18880

Alpha-macro-globulin thiol-ester bond-forming region, and Membrane attack complex

3 of 24

2.2

1.81

0.00034

CL:18918

Alpha-macro-globulin thiol-ester bond-forming region, and CUB domain

2 of 5

2.7

1.38

0.0031

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8939243

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

5 of 27

2.37

3.76

3.60e-08

MAP-8943724

Regulation of PTEN gene transcription

5 of 40

2.2

3.39

1.09e-07

MAP-2559580

Oxidative Stress Induced Senescence

5 of 57

2.04

3.01

3.81e-07

MAP-6807070

PTEN Regulation

5 of 75

1.92

2.7

1.06e-06

MAP-3108214

SUMOylation of DNA damage response and repair proteins

4 of 41

2.09

2.52

7.47e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031519

PcG protein complex

3 of 20

2.28

1.6

0.00096

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17208

RNA binding Region

2 of 2

3.1

1.23

0.0061

PF16207

RAWUL domain RING finger- and WD40-associated ubiquitin-like

2 of 4

2.8

1.17

0.0077

PF12140

SLED domain

2 of 5

2.7

1.16

0.0077

PF02008

CXXC zinc finger domain

2 of 5

2.7

1.16

0.0077

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

2 of 9

2.45

0.9

0.0223

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