STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIR89148.1Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. (240 aa)    
Predicted Functional Partners:
hisE
phosphoribosyl-ATP pyrophosphatase.
      0.977
SIR89246.1
tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
      0.895
SIR89131.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
    0.795
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
       0.726
SIS20048.1
Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED.
  
     0.708
SIS00395.1
Kojibiose phosphorylase.
 
 
 0.678
guaA
GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.
  
 
  0.662
SIR89113.1
Predicted ATP-dependent carboligase, ATP-grasp superfamily.
 
     0.656
SIS17833.1
Trehalose 6-phosphatase.
    
 0.633
SIR70047.1
Alpha,alpha-trehalose phosphorylase.
 
 
 0.630
Your Current Organism:
Williamsia sterculiae
NCBI taxonomy Id: 1344003
Other names: CPCC 203464, DSM 45741, KCTC 29118, W. sterculiae, Williamsia sp. I12A-00824, Williamsia sp. I12A-01109, Williamsia sterculiae Fang et al. 2013, strain I12A-01109
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