STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egtDL-histidine Nalpha-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (327 aa)    
Predicted Functional Partners:
egtB
iron(II)-dependent oxidoreductase; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family.
 
 0.999
egtC
Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
 
 0.998
egtA
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
 
  
 0.970
SIR78284.1
Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain; Manually curated.
 
 
 0.833
SIR88641.1
Protein of unknown function DUF58.
      
 0.777
purD
Phosphoribosylamine--glycine ligase; Belongs to the GARS family.
      
 0.773
SIR99086.1
Carotenoid cleavage dioxygenase.
      
 0.754
SIR75644.1
Citrate lyase subunit beta / citryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family.
      
 0.644
SIR64514.1
Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family.
   
    0.586
SIS00220.1
Uncharacterized conserved protein, DUF427 family.
 
     0.547
Your Current Organism:
Williamsia sterculiae
NCBI taxonomy Id: 1344003
Other names: CPCC 203464, DSM 45741, KCTC 29118, W. sterculiae, Williamsia sp. I12A-00824, Williamsia sp. I12A-01109, Williamsia sterculiae Fang et al. 2013, strain I12A-01109
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