SIS17689.1 protein (Williamsia sterculiae) - STRING interaction network

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

SIS17689.1

4-amino-4-deoxy-L-arabinose transferase. (730 aa)

Predicted Functional Partners:

SIS17696.1

0.971

SIS17702.1

0.555

SIS17747.1

0.465

SIS17754.1

0.465

SIS17760.1

0.465

Your Current Organism:

Williamsia sterculiae

NCBI taxonomy Id: 1344003
Other names: CPCC 203464, DSM 45741, KCTC 29118, W. sterculiae, Williamsia sp. I12A-00824, Williamsia sp. I12A-01109, Williamsia sterculiae Fang et al. 2013, strain I12A-01109

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIS17689.1	SIS17696.1	SAMN05445060_3298	SAMN05445060_3299	4-amino-4-deoxy-L-arabinose transferase.	GtrA-like protein.	0.971
SIS17689.1	SIS17702.1	SAMN05445060_3298	SAMN05445060_3300	4-amino-4-deoxy-L-arabinose transferase.	Diadenosine tetraphosphate (Ap4A) hydrolase.	0.555
SIS17689.1	SIS17747.1	SAMN05445060_3298	SAMN05445060_3301	4-amino-4-deoxy-L-arabinose transferase.	Hypothetical protein.	0.465
SIS17689.1	SIS17754.1	SAMN05445060_3298	SAMN05445060_3302	4-amino-4-deoxy-L-arabinose transferase.	Two-component system, OmpR family, sensor kinase.	0.465
SIS17689.1	SIS17760.1	SAMN05445060_3298	SAMN05445060_3303	4-amino-4-deoxy-L-arabinose transferase.	Two component transcriptional regulator, winged helix family.	0.465
SIS17696.1	SIS17689.1	SAMN05445060_3299	SAMN05445060_3298	GtrA-like protein.	4-amino-4-deoxy-L-arabinose transferase.	0.971
SIS17696.1	SIS17702.1	SAMN05445060_3299	SAMN05445060_3300	GtrA-like protein.	Diadenosine tetraphosphate (Ap4A) hydrolase.	0.588
SIS17696.1	SIS17747.1	SAMN05445060_3299	SAMN05445060_3301	GtrA-like protein.	Hypothetical protein.	0.465
SIS17696.1	SIS17754.1	SAMN05445060_3299	SAMN05445060_3302	GtrA-like protein.	Two-component system, OmpR family, sensor kinase.	0.559
SIS17696.1	SIS17760.1	SAMN05445060_3299	SAMN05445060_3303	GtrA-like protein.	Two component transcriptional regulator, winged helix family.	0.468
SIS17702.1	SIS17689.1	SAMN05445060_3300	SAMN05445060_3298	Diadenosine tetraphosphate (Ap4A) hydrolase.	4-amino-4-deoxy-L-arabinose transferase.	0.555
SIS17702.1	SIS17696.1	SAMN05445060_3300	SAMN05445060_3299	Diadenosine tetraphosphate (Ap4A) hydrolase.	GtrA-like protein.	0.588
SIS17702.1	SIS17747.1	SAMN05445060_3300	SAMN05445060_3301	Diadenosine tetraphosphate (Ap4A) hydrolase.	Hypothetical protein.	0.658
SIS17702.1	SIS17754.1	SAMN05445060_3300	SAMN05445060_3302	Diadenosine tetraphosphate (Ap4A) hydrolase.	Two-component system, OmpR family, sensor kinase.	0.754
SIS17702.1	SIS17760.1	SAMN05445060_3300	SAMN05445060_3303	Diadenosine tetraphosphate (Ap4A) hydrolase.	Two component transcriptional regulator, winged helix family.	0.658
SIS17747.1	SIS17689.1	SAMN05445060_3301	SAMN05445060_3298	Hypothetical protein.	4-amino-4-deoxy-L-arabinose transferase.	0.465
SIS17747.1	SIS17696.1	SAMN05445060_3301	SAMN05445060_3299	Hypothetical protein.	GtrA-like protein.	0.465
SIS17747.1	SIS17702.1	SAMN05445060_3301	SAMN05445060_3300	Hypothetical protein.	Diadenosine tetraphosphate (Ap4A) hydrolase.	0.658
SIS17747.1	SIS17754.1	SAMN05445060_3301	SAMN05445060_3302	Hypothetical protein.	Two-component system, OmpR family, sensor kinase.	0.773
SIS17747.1	SIS17760.1	SAMN05445060_3301	SAMN05445060_3303	Hypothetical protein.	Two component transcriptional regulator, winged helix family.	0.773

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.735

expected number of edges:

10

PPI enrichment p-value:

0.000502

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

7 of 22

2.68

6.72

7.27e-14

GO:1902600

Proton transmembrane transport

7 of 88

2.07

4.44

6.34e-11

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

4 of 12

2.7

3.81

7.16e-08

GO:0061469

Regulation of type B pancreatic cell proliferation

2 of 9

2.52

1.33

0.0036

GO:0006796

Phosphate-containing compound metabolic process

10 of 1477

1.0

1.19

1.27e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

7 of 89

2.07

4.29

1.62e-10

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 10

2.78

3.68

1.46e-07

GO:0043027

Cysteine-type endopeptidase inhibitor activity involved in apoptotic process

2 of 10

2.48

1.19

0.0065

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

7 of 18

2.76

7.47

3.25e-15

GO:0032133

Chromosome passenger complex

4 of 7

2.93

4.35

9.43e-09

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 5

2.95

3.16

1.64e-06

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 12

2.57

2.65

1.11e-05

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

2 of 3

3.0

1.98

0.00026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22668

Mitochondrial proton-transporting ATP synthase complex

7 of 13

2.91

7.82

1.38e-15

CL:22670

CF(1), and Formation of ATP by chemiosmotic coupling

5 of 6

3.09

5.83

1.85e-11

CL:8092

Mixed, incl. Spindle midzone, and Kinesin motor, catalytic domain. ATPase.

4 of 43

2.14

2.58

6.61e-06

CL:8120

Chromosome passenger complex, and Activation of NIMA Kinases NEK9, NEK6, NEK7

3 of 12

2.57

2.43

2.92e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 166

1.86

4.18

4.21e-12

map01100

Metabolic pathways

8 of 2460

0.69

0.52

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

7 of 18

2.76

7.43

4.12e-15

MAP-8949613

Cristae formation

7 of 27

2.59

6.82

2.30e-14

MAP-1592230

Mitochondrial biogenesis

7 of 50

2.32

5.69

7.50e-13

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

7 of 120

1.94

3.97

1.87e-10

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

7 of 178

1.77

3.26

2.17e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

3 of 40

2.05

2.27

2.44e-05

BTO:0000562

Heart

4 of 233

1.41

1.53

5.79e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

7 of 29

2.56

6.57

6.48e-14

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

4 of 11

2.73

3.81

7.47e-08

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

4 of 14

2.63

3.66

1.25e-07

GOCC:0032133

Chromosome passenger complex

3 of 4

3.05

3.13

1.97e-06

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 15

2.48

2.38

3.43e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

3 of 26

2.24

1.85

0.00029

KW-0139

CF(1)

2 of 4

2.87

1.63

0.0011

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00238

Baculoviral inhibition of apoptosis protein repeat

2 of 7

2.63

1.08

0.0109

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