A0A138ZX50 protein (Gonapodya prolifera) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A138ZX50

Uncharacterized protein. (282 aa)

Predicted Functional Partners:

A0A139ATP6

0.682

A0A139APN2

0.658

A0A139AZR1

0.550

A0A138ZY00

0.520

A0A138ZYS7

0.520

A0A139A340

0.520

A0A139A997

0.520

A0A139AQ51

0.520

A0A139AUT3

0.506

A0A139ACN4

0.490

Your Current Organism:

Gonapodya prolifera

NCBI taxonomy Id: 1344416
Other names: G. prolifera JEL478, Gonapodya prolifera JEL478

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A138ZX50	A0A138ZY00	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A138ZX50	A0A138ZYS7	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A138ZX50	A0A139A340	Uncharacterized protein.	Carbohydrate-binding module family 1 protein.	0.520
A0A138ZX50	A0A139A997	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A138ZX50	A0A139ACN4	Uncharacterized protein.	Kinase-like protein.	0.490
A0A138ZX50	A0A139APN2	Uncharacterized protein.	Uncharacterized protein.	0.658
A0A138ZX50	A0A139AQ51	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A138ZX50	A0A139ATP6	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.682
A0A138ZX50	A0A139AUT3	Uncharacterized protein.	ZZ-type domain-containing protein.	0.506
A0A138ZX50	A0A139AZR1	Uncharacterized protein.	Uncharacterized protein.	0.550
A0A138ZY00	A0A138ZX50	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A138ZY00	A0A139ACN4	Uncharacterized protein.	Kinase-like protein.	0.900
A0A138ZY00	A0A139APN2	Uncharacterized protein.	Uncharacterized protein.	0.748
A0A138ZY00	A0A139ATP6	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.712
A0A138ZYS7	A0A138ZX50	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A138ZYS7	A0A139ACN4	Uncharacterized protein.	Kinase-like protein.	0.900
A0A138ZYS7	A0A139APN2	Uncharacterized protein.	Uncharacterized protein.	0.748
A0A138ZYS7	A0A139ATP6	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.712
A0A139A340	A0A138ZX50	Carbohydrate-binding module family 1 protein.	Uncharacterized protein.	0.520
A0A139A340	A0A139ACN4	Carbohydrate-binding module family 1 protein.	Kinase-like protein.	0.900

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.904

expected number of edges:

26

PPI enrichment p-value:

0.86

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006310

DNA recombination

8 of 68

2.02

4.65

4.87e-12

GO:0000724

Double-strand break repair via homologous recombination

6 of 37

2.15

4.06

1.85e-09

GO:0006302

Double-strand break repair

7 of 64

1.98

3.97

4.14e-10

GO:0000730

DNA recombinase assembly

4 of 5

2.85

3.91

5.80e-08

GO:0006312

Mitotic recombination

4 of 12

2.47

3.31

4.47e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140664

ATP-dependent DNA damage sensor activity

4 of 14

2.4

2.89

2.75e-06

GO:0008094

ATP-dependent activity, acting on DNA

5 of 68

1.81

2.42

2.87e-06

GO:0140097

Catalytic activity, acting on DNA

6 of 121

1.64

2.19

2.75e-06

GO:0000150

DNA strand exchange activity

2 of 3

2.77

1.59

0.0013

GO:0003697

Single-stranded DNA binding

3 of 31

1.93

1.56

0.00075

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033061

DNA recombinase mediator complex

3 of 4

2.82

2.49

2.75e-05

GO:0005694

Chromosome

4 of 298

1.07

0.61

0.0265

GO:0005634

Nucleus

10 of 1915

0.66

0.56

0.00030

GO:0043231

Intracellular membrane-bounded organelle

11 of 3750

0.41

0.32

0.0071

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3707

Homologous recombination, and DNA secondary structure binding

10 of 29

2.48

9.3

4.91e-21

CL:3705

Mismatch repair, and Homologous recombination

11 of 65

2.17

7.84

4.91e-21

CL:3709

Mixed, incl. HDR through Single Strand Annealing (SSA), and Sensing of DNA Double Strand Breaks

6 of 23

2.36

5.13

2.61e-11

CL:3712

HDR through Single Strand Annealing (SSA), and DNA replication factor A complex

4 of 8

2.64

3.84

5.62e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03440

Homologous recombination

8 of 48

2.17

5.87

1.74e-14

map03430

Mismatch repair

3 of 46

1.76

1.37

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5685942

HDR through Homologous Recombination (HRR)

8 of 23

2.49

7.5

2.06e-16

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

9 of 36

2.34

7.45

2.15e-17

MAP-5693538

Homology Directed Repair

9 of 37

2.33

7.41

2.15e-17

MAP-5693579

Homologous DNA Pairing and Strand Exchange

7 of 13

2.68

7.37

2.95e-15

MAP-5693616

Presynaptic phase of homologous DNA pairing and strand exchange

6 of 12

2.64

6.15

9.79e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033061

DNA recombinase mediator complex

3 of 4

2.82

2.44

3.40e-05

GOCC:0033063

Rad51B-Rad51C-Rad51D-XRCC2 complex

2 of 2

2.95

1.39

0.0031

GOCC:0005634

Nucleus

7 of 1123

0.74

0.5

0.0111

GOCC:0043229

Intracellular organelle

11 of 3327

0.46

0.37

0.0031

GOCC:0043231

Intracellular membrane-bounded organelle

9 of 2475

0.51

0.34

0.0228

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

4 of 243

1.16

0.64

0.0275

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027417

P-loop containing nucleoside triphosphate hydrolase

7 of 335

1.27

1.36

4.81e-05

IPR020588

DNA recombination and repair protein RecA-like, ATP-binding domain

2 of 2

2.95

1.13

0.0091

IPR013632

DNA recombination and repair protein Rad51-like, C-terminal

2 of 2

2.95

1.13

0.0091

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