A0A139AF62 protein (Gonapodya prolifera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A139AF62

Putative zinc-binding oxidoreductase. (337 aa)

Predicted Functional Partners:

A0A139A279

0.741

A0A139AR42

0.741

A0A138ZZV1

0.740

A0A139AE55

0.552

KATNAL2

0.545

A0A139A4D3

0.543

A0A139ADP5

0.543

A0A138ZYL0

0.536

A0A138ZYP4

0.536

A0A139A2U1

0.536

Your Current Organism:

Gonapodya prolifera

NCBI taxonomy Id: 1344416
Other names: G. prolifera JEL478, Gonapodya prolifera JEL478

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A138ZYL0	A0A139AE55	A0A138ZYL0	A0A139AE55	Thiolase-like protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	NAD(P)-binding protein.	0.639
A0A138ZYL0	A0A139AF62	A0A138ZYL0	A0A139AF62	Thiolase-like protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	Putative zinc-binding oxidoreductase.	0.536
A0A138ZYP4	A0A139AE55	A0A138ZYP4	A0A139AE55	Lactoylglutathione lyase.	NAD(P)-binding protein.	0.639
A0A138ZYP4	A0A139AF62	A0A138ZYP4	A0A139AF62	Lactoylglutathione lyase.	Putative zinc-binding oxidoreductase.	0.536
A0A138ZZV1	A0A139A279	A0A138ZZV1	A0A139A279	Molybdopterin binding oxidoreductase.	Molybdopterin binding oxidoreductase.	0.905
A0A138ZZV1	A0A139AF62	A0A138ZZV1	A0A139AF62	Molybdopterin binding oxidoreductase.	Putative zinc-binding oxidoreductase.	0.740
A0A138ZZV1	A0A139AR42	A0A138ZZV1	A0A139AR42	Molybdopterin binding oxidoreductase.	Uncharacterized protein.	0.895
A0A139A279	A0A138ZZV1	A0A139A279	A0A138ZZV1	Molybdopterin binding oxidoreductase.	Molybdopterin binding oxidoreductase.	0.905
A0A139A279	A0A139AE55	A0A139A279	A0A139AE55	Molybdopterin binding oxidoreductase.	NAD(P)-binding protein.	0.679
A0A139A279	A0A139AF62	A0A139A279	A0A139AF62	Molybdopterin binding oxidoreductase.	Putative zinc-binding oxidoreductase.	0.741
A0A139A279	A0A139AR42	A0A139A279	A0A139AR42	Molybdopterin binding oxidoreductase.	Uncharacterized protein.	0.951
A0A139A2U1	A0A139AE55	A0A139A2U1	A0A139AE55	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase.	NAD(P)-binding protein.	0.639
A0A139A2U1	A0A139AF62	A0A139A2U1	A0A139AF62	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase.	Putative zinc-binding oxidoreductase.	0.536
A0A139A4D3	A0A139AF62	A0A139A4D3	A0A139AF62	Phosphotransferase.	Putative zinc-binding oxidoreductase.	0.543
A0A139ADP5	A0A139AF62	A0A139ADP5	A0A139AF62	Phosphotransferase.	Putative zinc-binding oxidoreductase.	0.543
A0A139AE55	A0A138ZYL0	A0A139AE55	A0A138ZYL0	NAD(P)-binding protein.	Thiolase-like protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.639
A0A139AE55	A0A138ZYP4	A0A139AE55	A0A138ZYP4	NAD(P)-binding protein.	Lactoylglutathione lyase.	0.639
A0A139AE55	A0A139A279	A0A139AE55	A0A139A279	NAD(P)-binding protein.	Molybdopterin binding oxidoreductase.	0.679
A0A139AE55	A0A139A2U1	A0A139AE55	A0A139A2U1	NAD(P)-binding protein.	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase.	0.639
A0A139AE55	A0A139AF62	A0A139AE55	A0A139AF62	NAD(P)-binding protein.	Putative zinc-binding oxidoreductase.	0.552

page 1 of 2

Network Stats

number of nodes:

10

number of edges:

16

average node degree:

3.2

avg. local clustering coefficient:

0.869

expected number of edges:

9

PPI enrichment p-value:

0.0237

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019430

Removal of superoxide radicals

2 of 4

2.58

1.17

0.0072

GO:0006537

Glutamate biosynthetic process

2 of 4

2.58

1.17

0.0072

GO:0098869

Cellular oxidant detoxification

3 of 25

1.96

1.11

0.0072

GO:0006541

Glutamine metabolic process

2 of 23

1.82

0.84

0.0235

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051538

3 iron, 4 sulfur cluster binding

2 of 2

2.88

1.48

0.0021

GO:0016041

Glutamate synthase (ferredoxin) activity

2 of 2

2.88

1.48

0.0021

GO:0004791

Thioredoxin-disulfide reductase activity

2 of 2

2.88

1.48

0.0021

GO:0015035

Protein-disulfide reductase activity

3 of 17

2.12

1.47

0.0015

GO:0016491

Oxidoreductase activity

6 of 436

1.02

0.81

0.0021

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00450

Selenocompound metabolism

5 of 22

2.23

3.8

1.46e-08

map00910

Nitrogen metabolism

3 of 28

1.91

1.62

0.00050

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

4 of 53

1.76

2.16

1.08e-05

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 110

1.44

1.52

8.77e-05

MAP-5663205

Infectious disease

4 of 117

1.41

1.49

8.77e-05

MAP-1643685

Disease

4 of 120

1.4

1.48

8.77e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04898

Glutamate synthase central domain

2 of 2

2.88

1.18

0.0074

PF01493

GXGXG motif

2 of 2

2.88

1.18

0.0074

PF00310

Glutamine amidotransferases class-II

2 of 2

2.88

1.18

0.0074

PF01645

Conserved region in glutamate synthase

2 of 3

2.7

1.17

0.0074

PF00890

FAD binding domain

2 of 12

2.1

0.88

0.0222

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023753

FAD/NAD(P)-binding domain

4 of 15

2.3

2.54

1.21e-05

IPR036188

FAD/NAD(P)-binding domain superfamily

4 of 52

1.76

1.53

0.00056

IPR036485

Glutamate synthase, alpha subunit, C-terminal domain superfamily

2 of 2

2.88

1.23

0.0060

IPR006982

Glutamate synthase, central-N

2 of 2

2.88

1.23

0.0060

IPR002932

Glutamate synthase domain

2 of 2

2.88

1.23

0.0060

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About