STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A139APE3DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (964 aa)    
Predicted Functional Partners:
A0A139ATW4
P-loop containing nucleoside triphosphate hydrolase protein.
   
 0.999
A0A139AWE5
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.999
A0A138ZXL7
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
  
 0.989
A0A139ARZ2
Uncharacterized protein.
  
 0.972
A0A139AYN0
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.972
A0A139ANA2
Nucleic acid-binding protein.
    
 0.957
A0A139A019
ERCC4 domain-containing protein.
    
 0.913
A0A138ZYX0
DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.
  
 0.912
A0A139AZN4
SAS-6_N domain-containing protein.
    
 0.890
A0A139AJR7
Uncharacterized protein.
    
 0.877
Your Current Organism:
Gonapodya prolifera
NCBI taxonomy Id: 1344416
Other names: G. prolifera JEL478, Gonapodya prolifera JEL478
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