A0A139AVL9 protein (Gonapodya prolifera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A139AVL9

GroES-like protein. (357 aa)

Predicted Functional Partners:

A0A139A279

0.741

A0A139AR42

0.741

A0A138ZZV1

0.740

A0A138ZZW8

0.560

A0A139AE55

0.552

KATNAL2

0.545

A0A138ZYL0

0.536

A0A138ZYP4

0.536

A0A139A2U1

0.536

A0A139ACA5

0.536

Your Current Organism:

Gonapodya prolifera

NCBI taxonomy Id: 1344416
Other names: G. prolifera JEL478, Gonapodya prolifera JEL478

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A138ZYL0	A0A138ZZW8	A0A138ZYL0	A0A138ZZW8	Thiolase-like protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	PKS_ER domain-containing protein.	0.529
A0A138ZYL0	A0A139AE55	A0A138ZYL0	A0A139AE55	Thiolase-like protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	NAD(P)-binding protein.	0.639
A0A138ZYL0	A0A139AVL9	A0A138ZYL0	A0A139AVL9	Thiolase-like protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	GroES-like protein.	0.536
A0A138ZYP4	A0A138ZZW8	A0A138ZYP4	A0A138ZZW8	Lactoylglutathione lyase.	PKS_ER domain-containing protein.	0.529
A0A138ZYP4	A0A139AE55	A0A138ZYP4	A0A139AE55	Lactoylglutathione lyase.	NAD(P)-binding protein.	0.639
A0A138ZYP4	A0A139AVL9	A0A138ZYP4	A0A139AVL9	Lactoylglutathione lyase.	GroES-like protein.	0.536
A0A138ZZV1	A0A139A279	A0A138ZZV1	A0A139A279	Molybdopterin binding oxidoreductase.	Molybdopterin binding oxidoreductase.	0.905
A0A138ZZV1	A0A139AR42	A0A138ZZV1	A0A139AR42	Molybdopterin binding oxidoreductase.	Uncharacterized protein.	0.895
A0A138ZZV1	A0A139AVL9	A0A138ZZV1	A0A139AVL9	Molybdopterin binding oxidoreductase.	GroES-like protein.	0.740
A0A138ZZW8	A0A138ZYL0	A0A138ZZW8	A0A138ZYL0	PKS_ER domain-containing protein.	Thiolase-like protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.529
A0A138ZZW8	A0A138ZYP4	A0A138ZZW8	A0A138ZYP4	PKS_ER domain-containing protein.	Lactoylglutathione lyase.	0.529
A0A138ZZW8	A0A139A279	A0A138ZZW8	A0A139A279	PKS_ER domain-containing protein.	Molybdopterin binding oxidoreductase.	0.560
A0A138ZZW8	A0A139A2U1	A0A138ZZW8	A0A139A2U1	PKS_ER domain-containing protein.	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase.	0.529
A0A138ZZW8	A0A139ACA5	A0A138ZZW8	A0A139ACA5	PKS_ER domain-containing protein.	Glyoxalase/bleomycin resistance protein/dioxygenase.	0.529
A0A138ZZW8	A0A139AE55	A0A138ZZW8	A0A139AE55	PKS_ER domain-containing protein.	NAD(P)-binding protein.	0.740
A0A138ZZW8	A0A139AR42	A0A138ZZW8	A0A139AR42	PKS_ER domain-containing protein.	Uncharacterized protein.	0.560
A0A138ZZW8	A0A139AVL9	A0A138ZZW8	A0A139AVL9	PKS_ER domain-containing protein.	GroES-like protein.	0.560
A0A138ZZW8	KATNAL2	A0A138ZZW8	A0A139AGZ7	PKS_ER domain-containing protein.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.491
A0A139A279	A0A138ZZV1	A0A139A279	A0A138ZZV1	Molybdopterin binding oxidoreductase.	Molybdopterin binding oxidoreductase.	0.905
A0A139A279	A0A138ZZW8	A0A139A279	A0A138ZZW8	Molybdopterin binding oxidoreductase.	PKS_ER domain-containing protein.	0.560

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.735

expected number of edges:

10

PPI enrichment p-value:

0.000502

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

7 of 22

2.68

6.72

7.27e-14

GO:1902600

Proton transmembrane transport

7 of 88

2.07

4.44

6.34e-11

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

4 of 12

2.7

3.81

7.16e-08

GO:0061469

Regulation of type B pancreatic cell proliferation

2 of 9

2.52

1.33

0.0036

GO:0006796

Phosphate-containing compound metabolic process

10 of 1477

1.0

1.19

1.27e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

7 of 89

2.07

4.29

1.62e-10

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 10

2.78

3.68

1.46e-07

GO:0043027

Cysteine-type endopeptidase inhibitor activity involved in apoptotic process

2 of 10

2.48

1.19

0.0065

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

7 of 18

2.76

7.47

3.25e-15

GO:0032133

Chromosome passenger complex

4 of 7

2.93

4.35

9.43e-09

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 5

2.95

3.16

1.64e-06

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 12

2.57

2.65

1.11e-05

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

2 of 3

3.0

1.98

0.00026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22668

Mitochondrial proton-transporting ATP synthase complex

7 of 13

2.91

7.82

1.38e-15

CL:22670

CF(1), and Formation of ATP by chemiosmotic coupling

5 of 6

3.09

5.83

1.85e-11

CL:8092

Mixed, incl. Spindle midzone, and Kinesin motor, catalytic domain. ATPase.

4 of 43

2.14

2.58

6.61e-06

CL:8120

Chromosome passenger complex, and Activation of NIMA Kinases NEK9, NEK6, NEK7

3 of 12

2.57

2.43

2.92e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 166

1.86

4.18

4.21e-12

map01100

Metabolic pathways

8 of 2460

0.69

0.52

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

7 of 18

2.76

7.43

4.12e-15

MAP-8949613

Cristae formation

7 of 27

2.59

6.82

2.30e-14

MAP-1592230

Mitochondrial biogenesis

7 of 50

2.32

5.69

7.50e-13

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

7 of 120

1.94

3.97

1.87e-10

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

7 of 178

1.77

3.26

2.17e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

3 of 40

2.05

2.27

2.44e-05

BTO:0000562

Heart

4 of 233

1.41

1.53

5.79e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

7 of 29

2.56

6.57

6.48e-14

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

4 of 11

2.73

3.81

7.47e-08

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

4 of 14

2.63

3.66

1.25e-07

GOCC:0032133

Chromosome passenger complex

3 of 4

3.05

3.13

1.97e-06

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 15

2.48

2.38

3.43e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

3 of 26

2.24

1.85

0.00029

KW-0139

CF(1)

2 of 4

2.87

1.63

0.0011

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00238

Baculoviral inhibition of apoptosis protein repeat

2 of 7

2.63

1.08

0.0109

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About