STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A1D2VRA9DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1280 aa)    
Predicted Functional Partners:
A0A1D2VLR4
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.970
A0A1D2VGM7
Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.899
A0A1D2VPN5
P-loop containing nucleoside triphosphate hydrolase protein.
   
 
 0.837
A0A1D2VNU5
Ubiquitin-like protein.
    
 0.835
A0A1D2VMP1
Ubiquitin-like domain-containing protein.
    
 0.829
A0A1D2VQN3
Zf-MIZ-domain-containing protein.
    
 0.825
A0A1D2VLZ3
SUMO-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.824
A0A1D2VKG4
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 
 0.820
A0A1D2VH39
Uncharacterized protein.
  
 
 0.800
A0A1D2VCC6
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.790
Your Current Organism:
Ascoidea rubescens
NCBI taxonomy Id: 1344418
Other names: A. rubescens DSM 1968, Ascoidea rubescens DSM 1968
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