node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OI25_1561 | OI25_4028 | OI25_1561 | OI25_4028 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | 0.901 |
OI25_1561 | OI25_5414 | OI25_1561 | OI25_5414 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Aminotransferase class-V family protein; [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.905 |
OI25_1561 | OI25_909 | OI25_1561 | OI25_909 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Beta-eliminating lyase family protein; [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.905 |
OI25_1561 | glyA | OI25_1561 | OI25_934 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Beta-eliminating lyase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
OI25_1561 | glyA2 | OI25_1561 | OI25_4016 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
OI25_1561 | ilvA | OI25_1561 | OI25_1066 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.918 |
OI25_1561 | serB | OI25_1561 | OI25_3426 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | serB: phosphoserine phosphatase SerB; [E] COG0560 Phosphoserine phosphatase. | 0.912 |
OI25_1561 | trpA | OI25_1561 | OI25_5296 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.906 |
OI25_1561 | trpB | OI25_1561 | OI25_5298 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
OI25_4028 | OI25_1561 | OI25_4028 | OI25_1561 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.901 |
OI25_4028 | OI25_5414 | OI25_4028 | OI25_5414 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Aminotransferase class-V family protein; [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.905 |
OI25_4028 | OI25_909 | OI25_4028 | OI25_909 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Beta-eliminating lyase family protein; [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | 0.905 |
OI25_4028 | glyA | OI25_4028 | OI25_934 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Beta-eliminating lyase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
OI25_4028 | glyA2 | OI25_4028 | OI25_4016 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
OI25_4028 | ilvA | OI25_4028 | OI25_1066 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.918 |
OI25_4028 | serB | OI25_4028 | OI25_3426 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | serB: phosphoserine phosphatase SerB; [E] COG0560 Phosphoserine phosphatase. | 0.912 |
OI25_4028 | trpA | OI25_4028 | OI25_5296 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.906 |
OI25_4028 | trpB | OI25_4028 | OI25_5298 | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
OI25_5414 | OI25_1561 | OI25_5414 | OI25_1561 | Aminotransferase class-V family protein; [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.905 |
OI25_5414 | OI25_4028 | OI25_5414 | OI25_4028 | Aminotransferase class-V family protein; [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. | Sda_mono: L-serine ammonia-lyase; [E] COG1760 L-serine deaminase. | 0.905 |