node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OI25_1131 | OI25_3353 | OI25_1131 | OI25_3353 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | Aminotransferase class-V family protein; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.907 |
OI25_1131 | OI25_6700 | OI25_1131 | OI25_6700 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | Aconitase family protein; [E] COG0065 3-isopropylmalate dehydratase large subunit. | 0.988 |
OI25_1131 | ilvC | OI25_1131 | OI25_447 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.758 |
OI25_1131 | ilvD | OI25_1131 | OI25_5735 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | ilvD: dihydroxy-acid dehydratase; [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.947 |
OI25_1131 | ilvE | OI25_1131 | OI25_2138 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.968 |
OI25_1131 | leuA | OI25_1131 | OI25_2727 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.901 |
OI25_1131 | leuA-2 | OI25_1131 | OI25_444 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.900 |
OI25_1131 | leuC | OI25_1131 | OI25_5306 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.960 |
OI25_1131 | leuC-2 | OI25_1131 | OI25_5713 | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.959 |
OI25_3353 | OI25_1131 | OI25_3353 | OI25_1131 | Aminotransferase class-V family protein; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase. | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 0.907 |
OI25_3353 | ilvD | OI25_3353 | OI25_5735 | Aminotransferase class-V family protein; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase. | ilvD: dihydroxy-acid dehydratase; [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.912 |
OI25_3353 | ilvE | OI25_3353 | OI25_2138 | Aminotransferase class-V family protein; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.910 |
OI25_3353 | leuA | OI25_3353 | OI25_2727 | Aminotransferase class-V family protein; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.907 |
OI25_3353 | leuA-2 | OI25_3353 | OI25_444 | Aminotransferase class-V family protein; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.907 |
OI25_6700 | OI25_1131 | OI25_6700 | OI25_1131 | Aconitase family protein; [E] COG0065 3-isopropylmalate dehydratase large subunit. | HMGL-like family protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 0.988 |
OI25_6700 | ilvC | OI25_6700 | OI25_447 | Aconitase family protein; [E] COG0065 3-isopropylmalate dehydratase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.965 |
OI25_6700 | ilvD | OI25_6700 | OI25_5735 | Aconitase family protein; [E] COG0065 3-isopropylmalate dehydratase large subunit. | ilvD: dihydroxy-acid dehydratase; [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.914 |
OI25_6700 | ilvE | OI25_6700 | OI25_2138 | Aconitase family protein; [E] COG0065 3-isopropylmalate dehydratase large subunit. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.625 |
OI25_6700 | leuA | OI25_6700 | OI25_2727 | Aconitase family protein; [E] COG0065 3-isopropylmalate dehydratase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.988 |
OI25_6700 | leuA-2 | OI25_6700 | OI25_444 | Aconitase family protein; [E] COG0065 3-isopropylmalate dehydratase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.990 |