Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_1008Lipid A export ATP-binding/permease protein msbA; ABC-type multidrug transport system, ATPase and permease components. (250 aa)    
Predicted Functional Partners:
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
  0.814
dnaK-3
Molecular chaperone.
 
 0.804
dnaK-4
Heat shock protein 70; Molecular chaperone; Belongs to the heat shock protein 70 family.
  
  0.734
ccmA
Spermidine/putrescine import ATP-binding protein potA; ABC-type spermidine/putrescine transport systems, ATPase components.
  
  0.733
ACPL_1002
Hypothetical protein.
   
  0.720
cydCD
Multidrug resistance protein 2; ABC-type multidrug transport system, ATPase and permease components.
  
 
  0.719
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 
 0.701
ACPL_7402
Heat shock protein 70; Molecular chaperone.
  
  0.690
ACPL_5171
Transitional endoplasmic reticulum ATPase; ATPases of the AAA+ class.
  
 
  0.682
nrps1A
Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.673
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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