Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuAIsopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (464 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.985
leuD
Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.979
ilvE
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase.
  
 0.969
ilvD
Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.952
ilvH
Acetolactate synthase, small (regulatory) subunit.
 
 
 0.942
yngH
Biotin carboxylase.
  
 
 0.935
ACPL_1521
propionyl-CoA carboxylase beta chain; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta).
  
 0.935
ACPL_7566
Pyruvate carboxylase.
  
 
 0.935
accA
Biotin carboxylase.
  
 
 0.935
porA
Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit.
  
 
 0.930
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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