STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mpiPhosphomannose isomerase. (394 aa)    
Predicted Functional Partners:
ACPL_1061
Glucosamine 6-phosphate synthetase; Contains amidotransferase and phosphosugar isomerase domains.
  
 
 0.987
manB
Phosphomannomutase.
  
 
 0.978
pmmB
Phosphomannomutase.
  
 
 0.934
pgi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 
 0.924
pfkB
Fructokinase; Sugar kinases, ribokinase family.
 
  
 0.917
pfp
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
    
 0.914
glmS-2
Glucosamine-fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
 0.914
mpi-2
Phosphomannose isomerase.
  
  
 
0.910
frk2
Fructokinase; Sugar kinases, ribokinase family.
    
 0.906
glmS
Glucosamine-fructose-6-phosphate aminotransferase (isomerizing); Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains.
    
  0.905
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.