Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_1071Putative GMP synthase; Glutamine-hydrolyzing; Acetyltransferases, including N-acetylases of ribosomal proteins. (363 aa)    
Predicted Functional Partners:
secA
Protein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family.
       0.571
ACPL_2391
Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.
   
 0.532
ACPL_4207
Putative N-acetyltransferase; Acetyltransferases, including N-acetylases of ribosomal proteins.
  
     0.522
ACPL_4575
Putative ribosomal N-acetyltransferase ydaF; Acetyltransferases, including N-acetylases of ribosomal proteins.
  
     0.521
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.520
ACPL_870
IMP dehydrogenase/GMP reductase.
    
  0.520
ACPL_7809
Ribosomal-protein-alanine N-acetyltransferase; Acetyltransferases, including N-acetylases of ribosomal proteins.
  
   
 0.513
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
  0.504
ACPL_138
Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.
     
  0.500
ACPL_3604
Threonine dehydrogenase and related Zn-dependent dehydrogenases.
     
  0.500
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.