STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_1071Putative GMP synthase; Glutamine-hydrolyzing; Acetyltransferases, including N-acetylases of ribosomal proteins. (363 aa)    
Predicted Functional Partners:
secA
Protein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family.
       0.586
ACPL_2391
Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.
   
  0.547
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.536
ACPL_870
IMP dehydrogenase/GMP reductase.
    
  0.536
ACPL_4207
Putative N-acetyltransferase; Acetyltransferases, including N-acetylases of ribosomal proteins.
  
     0.522
ACPL_4575
Putative ribosomal N-acetyltransferase ydaF; Acetyltransferases, including N-acetylases of ribosomal proteins.
  
     0.521
ACPL_7809
Ribosomal-protein-alanine N-acetyltransferase; Acetyltransferases, including N-acetylases of ribosomal proteins.
  
   
 0.519
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
  0.501
ACPL_138
Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.
     
  0.499
ACPL_3604
Threonine dehydrogenase and related Zn-dependent dehydrogenases.
     
  0.499
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.