STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdc2Pyruvate decarboxylase isozyme 2; Membrane proteins related to metalloendopeptidases. (414 aa)    
Predicted Functional Partners:
ACPL_8084
Morphogenesis protein 1; Membrane proteins related to metalloendopeptidases.
  
   
 0.862
ACPL_1080
Macrolide export ATP-binding/permease protein macB; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
 
  
 0.771
ACPL_1303
Glycosyl transferase family protein; Membrane carboxypeptidase (penicillin-binding protein).
  
     0.692
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
       0.663
ACPL_8116
Glycosyl transferase family protein; Membrane carboxypeptidase (penicillin-binding protein).
  
     0.651
ftsE
Methionine import ATP-binding protein metN; Part of the ABC transporter FtsEX involved in cellular division.
 
   
 0.639
ACPL_4159
Glycosyl transferase family protein; Membrane carboxypeptidase (penicillin-binding protein).
  
     0.516
ACPL_8350
Membrane carboxypeptidase (penicillin-binding protein).
  
     0.510
ponA
Glycosyl transferase family protein; Membrane carboxypeptidase (penicillin-binding protein).
  
     0.506
adh
Threonine dehydrogenase and related Zn-dependent dehydrogenases.
     
  0.499
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.