Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pncANicotinamidase/pyrazinamidase; Amidases related to nicotinamidase. (193 aa)    
Predicted Functional Partners:
pncB
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 0.998
ACPL_4673
NAD-dependent protein deacetylases, SIR2 family.
   
 0.912
cobB-3
NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily.
   
 0.912
deoD
Purine-nucleoside phosphorylase.
    
  0.902
ACPL_1165
Mov34/MPN/PAD-1 family protein; Predicted metal-dependent protease of the PAD1/JAB1 superfamily.
   
   0.672
clpS
ATP-dependent Clp protease adapter protein clpS; Belongs to the ClpS family.
       0.620
rpsL
30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
  
  
 0.611
ACPL_1164
Uncharacterized protein; 4-aminobutyrate aminotransferase and related aminotransferases.
       0.591
inhA
Enoyl-[acyl-carrier protein] reductase I; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
     
 0.585
tlyA
Predicted rRNA methylase.
     
 0.583
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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