STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_125Uncharacterized protein. (244 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.907
ACPL_538
Uncharacterized protein.
  
     0.749
ACPL_1534
Uncharacterized protein.
  
     0.707
ACPL_547
Uncharacterized protein.
  
     0.702
ACPL_7482
Putative NAD(P)H-dependent FMN-containing oxidoreductase ywqN; Multimeric flavodoxin WrbA.
  
  
 0.681
ACPL_2216
Uncharacterized protein containing LysM domain.
   
    0.637
ACPL_5886
Otogelin; HRD ubiquitin ligase complex, ER membrane component.
   
    0.637
wrbA
Trp repressor binding protein; Multimeric flavodoxin WrbA; Belongs to the WrbA family.
   
  
 0.637
gyrA-2
Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit.
  
  
 0.636
ACPL_120
Uncharacterized protein; Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives.
 
     0.612
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.