STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysGuroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Uroporphyrinogen-III methylase. (402 aa)    
Predicted Functional Partners:
hemD
Uroporphyrinogen-III synthase.
 
 
0.997
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.996
sat1
Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
 
  
 0.993
cobI
Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Precorrin-3B methylase.
 
 
0.992
sirB
Sirohydrochlorin ferrochelatase.
 
 0.989
nirA
Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.977
ACPL_2567
Uroporphyrinogen-III synthase.
 
 
 0.975
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.975
ACPL_832
Uroporphyrinogen-III synthase.
 
 
 0.974
ACPL_7559
Sirohydrochlorin cobaltochelatase.
 
  
 0.969
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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