Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_1425Hypothetical protein. (305 aa)    
Predicted Functional Partners:
metH
5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.968
ACPL_7391
Methionine synthase vitamin-B12 independent.
  
  
 0.866
gltB
Glutamate synthase domain 2.
     
 0.809
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.666
mtnA
Methylthioribose-1-phosphate isomerase; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family; Belongs to the eIF-2B alpha/beta/delta subunits family.
  
  
 0.660
ACPL_1424
Uncharacterized protein.
       0.654
ACPL_1423
Haloacid dehalogenase domain protein hydrolase; Predicted phosphatases.
       0.642
proV
Methionine import ATP-binding protein metN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
   
  
 0.634
megL
Methionine-gamma-lyase; Cystathionine beta-lyases/cystathionine gamma-synthases.
  
 
 0.630
cysA
Cystathionine beta-lyases/cystathionine gamma-synthases.
  
 
 0.630
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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