Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pcrASuperfamily I DNA and RNA helicases. (643 aa)    
Predicted Functional Partners:
ACPL_7611
Superfamily I DNA and RNA helicases.
  
 0.864
ACPL_7625
Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.
 
 
  0.831
ACPL_7626
Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.
   
  0.824
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.801
ruvA
Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
 
 0.799
ACPL_1659
DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.
  
 
 0.767
ACPL_2506
Putative ATP-dependent DNA helicase yjcD; Superfamily I DNA and RNA helicases.
     
  0.744
pcrA-2
Superfamily I DNA and RNA helicases.
     
  0.744
ACPL_8324
Superfamily I DNA and RNA helicases.
 
  
  0.716
recQ
Superfamily II DNA helicase.
 
 0.689
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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