Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fabF3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (408 aa)    
Predicted Functional Partners:
fabD
S-malonyltransferase; Membrane protease subunits, stomatin/prohibitin homologs.
 
 0.999
fabH
3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.996
fabD-2
Acyl carrier protein malonyltransferase; Membrane protease subunits, stomatin/prohibitin homologs.
  
 0.992
fabH-2
3-oxoacyl-[acyl-carrier-protein] synthase III.
 
 
 0.991
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
 
 
 0.950
inhA
Enoyl-[acyl-carrier protein] reductase I; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
 
  
 0.939
baeN
Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.939
pks3A
Polyketide synthase modules and related proteins.
 
 
0.923
nrps1A
Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.904
nrps1B
Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.904
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.