STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_1568Hypothetical protein; Predicted enzyme related to lactoylglutathione lyase. (126 aa)    
Predicted Functional Partners:
ACPL_770
Hypothetical protein.
  
     0.686
ACPL_8325
Type 4 prepilin-like proteins leader peptide-processing enzyme; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases.
  
     0.572
ACPL_1569
GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.
       0.560
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
       0.560
ACPL_1664
Hypothetical protein.
  
     0.559
ACPL_8156
Uncharacterized protein conserved in bacteria.
  
     0.511
ACPL_3575
Hypothetical protein; Pyrimidine reductase, riboflavin biosynthesis.
 
     0.483
ACPL_4194
Peptidoglycan-binding domain 1 protein.
  
     0.472
ACPL_4172
Hypothetical protein; Zn-dependent hydrolases, including glyoxylases.
  
     0.469
ACPL_2645
Hypothetical protein.
  
     0.417
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.