ACPL_1569 protein (Actinoplanes sp. SE50110)

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Score

ACPL_1569

GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain. (256 aa)

Predicted Functional Partners:

glnE

0.890

guaB

0.853

ACPL_870

0.762

pheT

0.726

gltB

0.706

ACPL_2391

0.690

rplK

0.677

gmk

0.635

ACPL_4809

0.618

argS

0.568

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_1569	ACPL_2391	ACPL_1569	ACPL_2391	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.	0.690
ACPL_1569	ACPL_4809	ACPL_1569	ACPL_4809	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	Two-component system sensor protein; Signal transduction histidine kinase.	0.618
ACPL_1569	ACPL_870	ACPL_1569	ACPL_870	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	IMP dehydrogenase/GMP reductase.	0.762
ACPL_1569	argS	ACPL_1569	ACPL_1504	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	Arginyl-tRNA synthetase.	0.568
ACPL_1569	glnE	ACPL_1569	ACPL_1570	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.890
ACPL_1569	gltB	ACPL_1569	ACPL_1813	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	Glutamate synthase domain 2.	0.706
ACPL_1569	gmk	ACPL_1569	ACPL_6469	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.635
ACPL_1569	guaB	ACPL_1569	ACPL_869	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.853
ACPL_1569	pheT	ACPL_1569	ACPL_6441	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.726
ACPL_1569	rplK	ACPL_1569	ACPL_1840	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.677
ACPL_2391	ACPL_1569	ACPL_2391	ACPL_1569	Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	0.690
ACPL_2391	gltB	ACPL_2391	ACPL_1813	Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.	Glutamate synthase domain 2.	0.568
ACPL_2391	guaB	ACPL_2391	ACPL_869	Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.466
ACPL_2391	pheT	ACPL_2391	ACPL_6441	Inosine-5'-monophosphate dehydrogenase; FOG: CBS domain.	Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.469
ACPL_4809	ACPL_1569	ACPL_4809	ACPL_1569	Two-component system sensor protein; Signal transduction histidine kinase.	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	0.618
ACPL_4809	glnE	ACPL_4809	ACPL_1570	Two-component system sensor protein; Signal transduction histidine kinase.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.654
ACPL_4809	gltB	ACPL_4809	ACPL_1813	Two-component system sensor protein; Signal transduction histidine kinase.	Glutamate synthase domain 2.	0.865
ACPL_4809	guaB	ACPL_4809	ACPL_869	Two-component system sensor protein; Signal transduction histidine kinase.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.728
ACPL_4809	pheT	ACPL_4809	ACPL_6441	Two-component system sensor protein; Signal transduction histidine kinase.	Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.497
ACPL_870	ACPL_1569	ACPL_870	ACPL_1569	IMP dehydrogenase/GMP reductase.	GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain.	0.762