| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACPL_1564 | ACPL_4809 | ACPL_1564 | ACPL_4809 | Glutamine synthetase. | Two-component system sensor protein; Signal transduction histidine kinase. | 0.600 |
| ACPL_1564 | glnA | ACPL_1564 | ACPL_1578 | Glutamine synthetase. | Glutamine synthetase. | 0.924 |
| ACPL_1564 | glnB | ACPL_1564 | ACPL_7303 | Glutamine synthetase. | Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.778 |
| ACPL_1564 | glnD | ACPL_1564 | ACPL_7302 | Glutamine synthetase. | Uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.589 |
| ACPL_1564 | glnE | ACPL_1564 | ACPL_1570 | Glutamine synthetase. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.647 |
| ACPL_1564 | gltB | ACPL_1564 | ACPL_1813 | Glutamine synthetase. | Glutamate synthase domain 2. | 0.983 |
| ACPL_1569 | ACPL_4809 | ACPL_1569 | ACPL_4809 | GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain. | Two-component system sensor protein; Signal transduction histidine kinase. | 0.618 |
| ACPL_1569 | glnE | ACPL_1569 | ACPL_1570 | GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.890 |
| ACPL_1569 | gltB | ACPL_1569 | ACPL_1813 | GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain. | Glutamate synthase domain 2. | 0.706 |
| ACPL_4809 | ACPL_1564 | ACPL_4809 | ACPL_1564 | Two-component system sensor protein; Signal transduction histidine kinase. | Glutamine synthetase. | 0.600 |
| ACPL_4809 | ACPL_1569 | ACPL_4809 | ACPL_1569 | Two-component system sensor protein; Signal transduction histidine kinase. | GMP synthase; Glutamine-hydrolyzing; GMP synthase - Glutamine amidotransferase domain. | 0.618 |
| ACPL_4809 | glnA | ACPL_4809 | ACPL_1578 | Two-component system sensor protein; Signal transduction histidine kinase. | Glutamine synthetase. | 0.600 |
| ACPL_4809 | glnB | ACPL_4809 | ACPL_7303 | Two-component system sensor protein; Signal transduction histidine kinase. | Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.966 |
| ACPL_4809 | glnE | ACPL_4809 | ACPL_1570 | Two-component system sensor protein; Signal transduction histidine kinase. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.654 |
| ACPL_4809 | gltB | ACPL_4809 | ACPL_1813 | Two-component system sensor protein; Signal transduction histidine kinase. | Glutamate synthase domain 2. | 0.865 |
| ACPL_7089 | ACPL_7111 | ACPL_7089 | ACPL_7111 | Ribonuclease D. | Hypothetical protein. | 0.609 |
| ACPL_7089 | glnE | ACPL_7089 | ACPL_1570 | Ribonuclease D. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.670 |
| ACPL_7089 | rbpA-2 | ACPL_7089 | ACPL_2796 | Ribonuclease D. | Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family. | 0.590 |
| ACPL_7111 | ACPL_7089 | ACPL_7111 | ACPL_7089 | Hypothetical protein. | Ribonuclease D. | 0.609 |
| ACPL_7111 | glnE | ACPL_7111 | ACPL_1570 | Hypothetical protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.695 |
