typA protein (Actinoplanes sp. SE50110) - STRING interaction network

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Score

typA

GTP-binding protein lepA; Predicted membrane GTPase involved in stress response. (623 aa)

Predicted Functional Partners:

rplA

0.809

gltB

0.806

guaA

0.800

infC

0.711

ychF

0.711

rpsJ

0.702

ACPL_199

0.698

engA

0.698

tsf

0.687

rpoB

0.674

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_199	guaA	ACPL_199	ACPL_873	Putative ABC transporter; Predicted GTPases (dynamin-related).	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	0.486
ACPL_199	typA	ACPL_199	ACPL_1838	Putative ABC transporter; Predicted GTPases (dynamin-related).	GTP-binding protein lepA; Predicted membrane GTPase involved in stress response.	0.698
engA	guaA	ACPL_6311	ACPL_873	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	0.486
engA	rplA	ACPL_6311	ACPL_768	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.739
engA	tsf	ACPL_6311	ACPL_7260	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.612
engA	typA	ACPL_6311	ACPL_1838	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	GTP-binding protein lepA; Predicted membrane GTPase involved in stress response.	0.698
gltB	guaA	ACPL_1813	ACPL_873	Glutamate synthase domain 2.	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	0.926
gltB	rpoB	ACPL_1813	ACPL_773	Glutamate synthase domain 2.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.727
gltB	rpsJ	ACPL_1813	ACPL_781	Glutamate synthase domain 2.	30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.674
gltB	tsf	ACPL_1813	ACPL_7260	Glutamate synthase domain 2.	Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.681
gltB	typA	ACPL_1813	ACPL_1838	Glutamate synthase domain 2.	GTP-binding protein lepA; Predicted membrane GTPase involved in stress response.	0.806
guaA	ACPL_199	ACPL_873	ACPL_199	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	Putative ABC transporter; Predicted GTPases (dynamin-related).	0.486
guaA	engA	ACPL_873	ACPL_6311	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.486
guaA	gltB	ACPL_873	ACPL_1813	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	Glutamate synthase domain 2.	0.926
guaA	infC	ACPL_873	ACPL_6446	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.	0.550
guaA	rplA	ACPL_873	ACPL_768	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.953
guaA	rpoB	ACPL_873	ACPL_773	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.938
guaA	rpsJ	ACPL_873	ACPL_781	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.771
guaA	tsf	ACPL_873	ACPL_7260	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.788
guaA	typA	ACPL_873	ACPL_1838	GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP.	GTP-binding protein lepA; Predicted membrane GTPase involved in stress response.	0.800