STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa)    
Predicted Functional Partners:
citA
Citrate synthase; Belongs to the citrate synthase family.
 
 0.997
ACPL_2558
Citrate synthase.
 
 0.997
ACPL_5308
Citrate synthase; Belongs to the citrate synthase family.
 
 0.997
ACPL_549
Citrate synthase; Belongs to the citrate synthase family.
 
 0.997
icdA
Isocitrate dehydrogenases; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.996
sucA
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.
 
 0.976
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 
 0.965
prpB
Methylisocitrate lyase; PEP phosphonomutase and related enzymes.
 
 0.948
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.944
aceA
Isocitrate lyase.
   
 
 0.937
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.