STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_20143-methyl-2-oxobutanoate hydroxymethyltransferase; PEP phosphonomutase and related enzymes. (264 aa)    
Predicted Functional Partners:
pdc
Pyruvate dehydrogenase (cytochrome); Thiamine pyrophosphate-requiring enzymes; Belongs to the TPP enzyme family.
 
  
 0.710
ACPL_5158
Malate synthase; Belongs to the malate synthase family.
   
 
 0.682
ACPL_6612
Malate synthase.
   
 
 0.682
acnA
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.675
ACPL_7601
Hypothetical protein.
   
    0.645
mshD
Mycothiol biosynthesis acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
   
    0.645
prpB
Methylisocitrate lyase; PEP phosphonomutase and related enzymes.
  
     0.627
citA
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.572
ACPL_2558
Citrate synthase.
  
 
 0.572
ACPL_5308
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.572
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.