Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase. (391 aa)    
Predicted Functional Partners:
ACPL_8028
4-hydroxyphenylpyruvate dioxygenase and related hemolysins.
 
 0.998
fahA
Fumarylacetoacetase; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway).
 
  
 0.988
ACPL_2073
Hypothetical protein.
 
     0.942
mceE
methylmalonyl-CoA epimerase; Lactoylglutathione lyase and related lyases.
  
 
 0.831
ACPL_3155
Hypothetical protein.
  
 
 0.801
ACPL_8034
Hypothetical protein.
 
     0.699
hpcE
5-oxopent-3-ene-1,2,5- tricarboxylatedecarboxylas E; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases).
  
  
 0.655
ACPL_4165
5-carboxymethyl-2-hydroxymuconateDelta- isomerase; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway).
  
  
 0.599
ACPL_7349
5-carboxymethyl-2-hydroxymuconateDelta- isomerase; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway).
  
  
 0.599
ACPL_2133
Carbamoyl-phosphate synthase L chain ATP-binding protein; Acetyl/propionyl-CoA carboxylase, alpha subunit.
 
  
 0.553
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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