Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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bfrABacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (160 aa)    
Predicted Functional Partners:
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
     
 0.924
bfd
BFD domain-containing protein (2Fe-2S)-binding domain-containing protein.
     
 0.699
ACPL_3421
Osmosensitive K+ channel histidine kinase.
   
  
 0.654
ACPL_8227
Signal transduction histidine kinase.
   
  
 0.654
ACPL_4649
Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.
   
  
 0.592
katE
Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide.
  
  
 0.573
ACPL_3780
Magnesium or manganese-dependent protein phosphatase; FOG: PAS/PAC domain.
   
  
 0.535
ACPL_381
Phosphoserine phosphatase rsbX; Anti-sigma regulatory factor (Ser/Thr protein kinase).
   
  
 0.535
ACPL_397
Serine phosphatase RsbU, regulator of sigma subunit.
   
  
 0.535
ideR
Iron-dependent repressor ideR; Mn-dependent transcriptional regulator.
      
 0.511
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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