STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_2274Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (525 aa)    
Predicted Functional Partners:
ACPL_4649
Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.
 
0.998
ACPL_3427
Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.
 
 0.997
ACPL_4801
Signal transduction histidine kinase.
 
 0.996
ACPL_2013
Sensor histidine kinase and response regulator of a two component complex; Signal transduction histidine kinase.
 
 0.994
ACPL_2016
Sensor histidine kinase and response regulator of a two component complex; FOG: PAS/PAC domain.
 
 0.994
ACPL_2192
Signal transduction histidine kinase.
 
 0.994
phoR
Sensory box histidine kinase PhoR; Signal transduction histidine kinase.
 
0.993
barA
Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.
 
 
0.993
ACPL_4605
PAS/PAC sensor hybrid histidine kinase; FOG: PAS/PAC domain.
 
 
 0.993
ACPL_4809
Two-component system sensor protein; Signal transduction histidine kinase.
 
 
0.993
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.