Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pcaB3-carboxy-cis,cis-muconate cycloisomerase; Adenylosuccinate lyase. (367 aa)    
Predicted Functional Partners:
pcaH
Protocatechuate 3,4-dioxygenase beta subunit.
 
 
 0.998
pcaG
Protocatechuate 3,4-dioxygenase beta subunit.
 
 
 0.998
ACPL_2370
4-carboxymuconolactone decarboxylase; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
 
 
 0.996
purK
5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.976
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.975
purC
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family.
  
 
 0.975
purE
5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 
 0.975
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Phosphoribosylaminoimidazole (AIR) synthetase.
  
 
 0.974
purD
Phosphoribosylamine-glycine ligase; Belongs to the GARS family.
  
 
 0.971
ACPL_4034
Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit.
 
 
 0.957
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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