Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_25883-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (290 aa)    
Predicted Functional Partners:
msmA
NAD-dependent aldehyde dehydrogenases.
 
 
 0.930
ACPL_7671
NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.
  
 
 0.918
ACPL_7755
NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.
  
 
 0.918
gabT
4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
gabT-2
4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
prpE
Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
 
 
 0.844
ACPL_5569
Acyl-CoA dehydrogenases.
  
 
 0.835
accA
Biotin carboxylase.
  
 
 0.832
acs
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.817
ACPL_7032
Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
  
 
 0.817
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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