STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_2614Flotillin-2; Membrane protease subunits, stomatin/prohibitin homologs. (341 aa)    
Predicted Functional Partners:
ACPL_2615
Putative inorganic polyphosphate/ATP-NAD kinase; Predicted sugar kinase.
 
     0.906
ACPL_2613
NUDIX hydrolase; ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family.
 
     0.842
ACPL_2109
AAA ATPase central domain protein; ATP-dependent Zn proteases; Belongs to the AAA ATPase family.
   
 0.796
ftsH
Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.796
ACPL_5687
7,8-dihydro-8-oxoguanine triphosphatase; ADP-ribose pyrophosphatase.
 
     0.615
ACPL_7705
Rhomboid family member 1; Uncharacterized membrane protein (homolog of Drosophila rhomboid).
   
 0.595
ACPL_8265
Rhomboid family member 2; Uncharacterized membrane protein (homolog of Drosophila rhomboid).
   
 0.595
ACPL_6711
7,8-dihydro-8-oxoguanine triphosphatase; ADP-ribose pyrophosphatase.
 
     0.578
arc
Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
 
 0.552
ACPL_5052
Putative zinc protease; Predicted Zn-dependent peptidases.
 
 0.485
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.