STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdcPyruvate dehydrogenase (cytochrome); Thiamine pyrophosphate-requiring enzymes; Belongs to the TPP enzyme family. (587 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase, small (regulatory) subunit.
 
 0.997
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.961
porA
Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit.
  
 
 0.951
leuD
Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.949
ACPL_1974
L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases.
  
 
 0.936
ACPL_6088
L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases.
  
 
 0.936
leuC
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.932
ACPL_7154
Malate dehydrogenase (oxaloacetate-decarboxylating); Malic enzyme.
  
 
 0.924
ACPL_7551
Malate dehydrogenase (oxaloacetate-decarboxylating); Malic enzyme.
  
 
 0.924
pyk1
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.921
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.