Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_28155'-3' exonuclease (including N-terminal domain of PolI). (302 aa)    
Predicted Functional Partners:
ACPL_7611
Superfamily I DNA and RNA helicases.
 
 0.928
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.881
ACPL_7634
DNA polymerase sliding clamp subunit (PCNA homolog).
  
 0.817
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.804
ACPL_2816
3-oxoacyl-[acyl-carrier-protein] reductase; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
   0.797
dinG
Rad3-related DNA helicases.
   
 0.789
ligC-2
ATP-dependent DNA ligase.
  
 0.730
ACPL_526
DNA excision repair protein ERCC-3; DNA or RNA helicases of superfamily II.
    
 0.727
ACPL_7117
Uncharacterized protein; DNA or RNA helicases of superfamily II.
    
 0.727
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
 
 
 0.708
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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