STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_2961Isochorismatase hydrolase; Amidases related to nicotinamidase. (188 aa)    
Predicted Functional Partners:
ACPL_2960
Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; SAM-dependent methyltransferases.
       0.777
dhbB
Isochorismatase hydrolase; Amidases related to nicotinamidase.
  
     0.710
ACPL_2419
3-oxoacyl-[acyl-carrier protein] reductase; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
   
 0.534
nrps1A
Amino acid adenylation domain-containing protein; Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.515
nrps1B
Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.515
trpE-2
Salicylate synthetase; Anthranilate/para-aminobenzoate synthases component I.
    
 0.511
baeN
Thiotemplate mechanism natural product synthetase; Non-ribosomal peptide synthetase modules and related proteins.
  
 
 0.499
ACPL_6810
Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain.
 
    0.471
nnrE
Uncharacterized protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both [...]
  
    0.452
ACPL_2962
Transcriptional regulators.
       0.448
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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