Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACPL_3018Signal transduction histidine kinase. (467 aa)    
Predicted Functional Partners:
rcaC
Protein rcaC; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
   0.848
ACPL_2205
Two component transcriptional regulator, winged helix family; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.820
phoB-2
Phosphate regulon transcriptional regulatory protein phoB; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.820
tcrA-2
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.806
barA
Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.
  
 
 0.802
tcrA
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.798
ACPL_4809
Two-component system sensor protein; Signal transduction histidine kinase.
 
 
0.798
ACPL_7094
Two component transcriptional regulator, winged helix family; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.781
ACPL_580
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.770
ACPL_6136
Transcriptional regulatory protein yycF; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.762
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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