STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_3233Misshapen-like kinase 1. (886 aa)    
Predicted Functional Partners:
ACPL_7611
Superfamily I DNA and RNA helicases.
  
 
 0.796
ACPL_6765
Hypothetical protein; Predicted NTPase (NACHT family).
  
     0.715
ACPL_5793
Hypothetical protein.
  
 
 0.561
ACPL_6788
Hypothetical protein.
  
     0.521
dhaR
HTH-type transcriptional repressor dhaR; Transcriptional regulator.
  
     0.489
ACPL_7634
DNA polymerase sliding clamp subunit (PCNA homolog).
  
 
 0.425
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.423
ACPL_1408
Predicted transcriptional regulators.
  
     0.411
ACPL_1213
Chromosome partition protein smc; ATPase involved in DNA repair.
 
 
 
 0.402
ACPL_3234
Hypothetical protein.
       0.400
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.