Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_3336Serine phosphatase RsbU, regulator of sigma subunit. (594 aa)    
Predicted Functional Partners:
ACPL_2318
Signal transduction histidine kinase.
 
 
 0.861
barA
Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.
  
 
 0.856
ACPL_4809
Two-component system sensor protein; Signal transduction histidine kinase.
 
 
 0.855
ACPL_4800
Two-component system, cell cycle sensor kinase and response regulator; Signal transduction histidine kinase.
 
 
 0.810
ACPL_3337
binR-like DNA-invertase; From Transposon Tn552; Site-specific recombinases, DNA invertase Pin homologs.
       0.773
ACPL_3707
Sensor histidine kinase/response regulator; FOG: HAMP domain.
  
 
 0.771
ACPL_398
GAF sensor hybrid histidine kinase; FOG: HAMP domain.
  
 
 0.757
ACPL_2274
Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
  
 0.741
ACPL_2272
Diguanylate cyclase; FOG: GAF domain.
 
 
 
 0.724
ACPL_4649
Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.
  
 
 0.720
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.