Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_3339Two-component system, NarL family, sensor histidine kinase DesK; Signal transduction histidine kinase. (409 aa)    
Predicted Functional Partners:
ACPL_3818
Two-component system, NarL family, response regulator DesR; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
  0.976
ACPL_4299
yfiK-like uncharacterized transcriptional regulatory protein; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
  0.976
ACPL_5661
Two-component system, NarL family, response regulator DesR; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.
 
  0.976
ACPL_4117
Transcriptional regulatory protein uhpA; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.
  
  0.968
ACPL_4298
Two-component system, NarL family, sensor histidine kinase DesK; Signal transduction histidine kinase.
  
  
 
0.928
ACPL_3817
Two-component system, NarL family, sensor histidine kinase DesK; Signal transduction histidine kinase.
  
  
 
0.926
ACPL_3340
Hypothetical protein.
       0.655
ACPL_4297
ABC-type multidrug transport system, permease component.
 
    0.552
ACPL_5666
Signal transduction histidine kinase.
  
     0.484
ACPL_4137
Transcriptional regulator, LuxR family; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
   0.474
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.