STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Coexpression
Experiments
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[Homology]
Score
ACPL_3352Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); FOG: GAF domain. (423 aa)    
Predicted Functional Partners:
ACPL_398
GAF sensor hybrid histidine kinase; FOG: HAMP domain.
  
 
 0.959
phoR
Sensory box histidine kinase PhoR; Signal transduction histidine kinase.
  
 
 0.939
ACPL_3427
Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.
  
 
 0.939
ACPL_4649
Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.
 
 0.920
ACPL_6738
Signal transduction histidine kinase.
  
 
 0.920
barA
Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.
  
 
 0.908
ACPL_2318
Signal transduction histidine kinase.
 
 
 0.903
ACPL_2260
Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 0.891
ACPL_3707
Sensor histidine kinase/response regulator; FOG: HAMP domain.
  
 
 0.890
ACPL_4809
Two-component system sensor protein; Signal transduction histidine kinase.
  
 
 0.874
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.