Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dprAProtein smf; Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. (286 aa)    
Predicted Functional Partners:
ACPL_1391
ComE operon protein 3; Predicted membrane metal-binding protein.
 
  
 0.835
ACPL_7263
Uncharacterized protein; Predicted ATPase with chaperone activity.
 
 
 0.798
ACPL_3514
Hypothetical protein.
       0.718
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.623
ACPL_6938
Hypothetical protein; Orotate phosphoribosyltransferase.
  
 
 0.603
ACPL_7262
Uncharacterized protein; Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Belongs to the UPF0102 family.
 
  
 0.603
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.597
ACPL_4649
Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.
  
  
 0.582
hofD
Leader peptidase (prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
  
  
 0.578
ACPL_5898
Type 4 prepilin-like proteins leader peptide-processing enzyme; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases.
  
  
 0.578
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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