STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_3575Hypothetical protein; Pyrimidine reductase, riboflavin biosynthesis. (197 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.807
ACPL_3576
ADP-ribosylglycohydrolase.
       0.648
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.584
ACPL_3577
Macrolide export ATP-binding/permease protein macB; ABC-type antimicrobial peptide transport system, permease component.
  
    0.543
ACPL_2875
Hypothetical protein.
  
     0.537
ACPL_3578
Spermidine/putrescine import ATP-binding protein potA; ABC-type sugar transport systems, ATPase components.
       0.536
folC
FolC bifunctional protein; Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
     
 0.527
ACPL_2430
yurO-like uncharacterized ABC transporter extracellular-binding protein; ABC-type sugar transport system, periplasmic component.
  
     0.484
ACPL_1568
Hypothetical protein; Predicted enzyme related to lactoylglutathione lyase.
 
     0.483
ACPL_2851
Truncated hemoglobins.
  
     0.451
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.