STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acbC2-epi-5-epi-valiolone synthase; Catalyzes the cyclization of D-sedoheptulose 7-phosphate to 2-epi-5-epi-valiolone. Does not use ido-heptulose 7-phosphate and 3- deoxy-arabino-heptulosonate 7-phosphate. Involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Belongs to the sugar phosphate cyclases superfamily. EEVS family. (398 aa)    
Predicted Functional Partners:
acbM
2-epi-5-epi-valiolone 7-kinase; Catalyzes the conversion of 2-epi-5-epi-valiolone to 2-epi-5- epi-valiolone 7-phosphate. Involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Belongs to the ROK (NagC/XylR) family.
 
  
 0.992
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.974
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
  
 0.962
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.954
ACPL_6249
Glucose kinase; Transcriptional regulator/sugar kinase.
 
  
 0.928
acbO
2-epi-5-epi-valiolone-7-phosphate 2-epimerase; Involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. Catalyzes the 2-epimerisation of 2-epi-5- epivaliolone 7-phosphate to yield 5-epi-valiolone 7-phosphate. Belongs to the hyi family.
     
 0.908
ACPL_6250
3-dehydroquinate synthetase.
  
  
 
0.905
acbL
Cyclitol dehydrogenase.
 
   
 0.886
acbN
Cyclitol oxidoreductase.
     
 0.871
acbK
Acarbose 7-kinase; Catalyzes the phosphorylation of the alpha-glucosidase inhibitor acarbose. Phosphorylation of acarbose could be a resistance- like self-protection mechanism; Belongs to the carbohydrate kinase PfkB family.
     
 0.858
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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