STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACPL_3817Two-component system, NarL family, sensor histidine kinase DesK; Signal transduction histidine kinase. (399 aa)    
Predicted Functional Partners:
ACPL_3818
Two-component system, NarL family, response regulator DesR; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.995
ACPL_5661
Two-component system, NarL family, response regulator DesR; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.
 
 0.980
ACPL_4117
Transcriptional regulatory protein uhpA; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain.
  
 0.978
ACPL_4299
yfiK-like uncharacterized transcriptional regulatory protein; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 0.978
ACPL_3339
Two-component system, NarL family, sensor histidine kinase DesK; Signal transduction histidine kinase.
  
  
 
0.926
ACPL_4298
Two-component system, NarL family, sensor histidine kinase DesK; Signal transduction histidine kinase.
  
  
 
0.926
ACPL_3816
ABC-2 type transporter; ABC-type multidrug transport system, permease component.
 
  
 0.859
ACPL_3815
Spermidine/putrescine import ATP-binding protein potA; ABC-type sugar transport systems, ATPase components.
 
    0.807
ACPL_3814
Platelet-activating factor acetylhydrolase 2, cytoplasmic; Predicted dienelactone hydrolase.
       0.727
ACPL_5253
yxjL-like uncharacterized transcriptional regulatory protein; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
  
 
 0.709
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.